(Chotchinga mu ubongo, BBB)
Chotchinga cha magazi ndi ubongo ndi chimodzi mwazinthu zofunika kwambiri zodzitetezera mwa anthu.Amapangidwa ndi ma cell a ubongo capillary endothelial cell, glial cell, ndi choroid plexus, kulola mitundu yeniyeni ya mamolekyu amagazi kulowa muubongo ndi ma cell ena ozungulira, ndipo amatha kuletsa zinthu zovulaza zosiyanasiyana kulowa mu minofu yaubongo.Ubongo, monga gawo lachinsinsi komanso lofunika kwambiri la thupi la munthu, umayang'anira ntchito zingapo zofunika.Chotchinga chamagazi ndi ubongo chimatha kuletsa zinthu zovulaza m'magazi ndikuteteza chitetezo cha minofu yaubongo.
Matenda a Alzheimer, AD
Matenda a Alzheimer's (AD) ndi matenda a neurodegenerative omwe amayamba mwachibwanabwana.M'zochitika zachipatala, kusokonezeka maganizo kwakukulu kumadziwika ndi kuwonongeka kwa kukumbukira, aphasia, aphasia, kutaya kuzindikira, kuwonongeka kwa luso la maso ndi malo, kusokonezeka kwa akuluakulu, ndi umunthu ndi kusintha kwa khalidwe.Etiology sichidziwikabe.Kusokonezeka maganizo msanga kumatanthauza anthu omwe amayamba zizindikiro asanakwanitse zaka 65;Anthu omwe amayamba kudwala dementia akakwanitsa zaka 65 amatchedwa senile dementia.Kupezeka kwa matenda a Alzheimer's (AD) nthawi zambiri kumalumikizidwa ndi mapuloteni a β- Amyloid (A β) Kuchuluka kwa mapuloteni a Tau amalumikizidwa, ndipo kafukufuku wochulukirapo akulemba pang'onopang'ono kuti neuroinflammation ndi imodzi mwazinthu zomwe zimapangitsa kuti AD ayambe.
Ndemanga: Kodi matenda a Alzheimer's ndi chiyani?Yang'anani pa chidziwitso ichi.People's Daily Online.2023-09-20
Dziwani kuti pali mtundu wina wa mabakiteriya omwe amatha kulowa m'magazi a ubongo
Posachedwapa, ofufuza ochokera ku Baylor College of Medicine ku United States adafalitsa pepala lofufuzira lotchedwa: Toll like receptor 4 ndi CD11b zosonyezedwa pa microglia coordinate erasure of Candida albicans cerebral mycosis mu magazini ya Cell Reports.
Tapeza bowa wotchedwa Candida albicans omwe amatha kulowa muubongo kudzera m'magazi.Monga momwe mwambi wotchuka umanenera, "Kukankha mwendo wa wolumala kungayambitse matenda a Alzheimer's ngati kusintha."Mu kafukufukuyu, tidawululanso njira zama cell zomwe ma Candida albicans amadutsa chotchinga chamagazi-muubongo ndikulowa muubongo, zomwe zimayambitsa matenda a Alzheimer's ngati kusintha.
Kodi Candida albicans amalowa bwanji muubongo?"Tinapeza kuti Candida albicans amapanga puloteni yotchedwa secreted aspartate protease (Saps), yomwe imasokoneza chotchinga cha magazi-muubongo, zomwe zimapangitsa kuti bowa lilowe mu ubongo ndikuwononga," adatero Dr. Yifan Wu, wasayansi wa ana pambuyo pachipatala omwe amagwira ntchito ku Corry. Laborator.
Candida albicans
Candida albicans (dzina la sayansi: Candida albicans) ndi yisiti yomwe imatha kuyambitsa matenda otengera mwayi.Nthawi zambiri amapezeka m'magulu a bakiteriya a m'mimba mwa anthu komanso mathirakiti a urogenital.Pafupifupi 40% mpaka 60% ya achikulire athanzi ali ndi ma Candida albicans m'matumbo awo am'kamwa ndi m'mimba.Candida albicans nthawi zambiri amakhala limodzi ndi thupi la munthu, koma amatha kuchulukirachulukira panthawi ya kuchepa kwa chitetezo chamthupi ndikuyambitsa candidiasis.Ndi mabakiteriya omwe amapezeka kwambiri mumtundu wa Candida
Malinga ndi kafukufuku yemwe adachitika mu Cell Reports, bowa omwe nthawi zambiri sitilabadira kwambiri amathanso kukhala amodzi mwa omwe amayambitsa matenda a Alzheimer's.Ofufuza ochokera ku Baylor School of Medicine ndi mabungwe ogwirizana apeza kudzera m'zinyama momwe ma Candida albicans amalowera muubongo komanso momwe amalumikizirana ndi njira ziwiri zodziyimira pawokha m'maselo aubongo omwe amalimbikitsa kuchotsedwa kwake (komwe kuli kofunikira kumvetsetsa kukula kwa matenda a Alzheimer's), ndipo apanga. β Amyloid protein (A β) Peptides (zidutswa zapoizoni zama protein a amyloid) amaonedwa kuti ndiye maziko a chitukuko cha matenda a Alzheimer's.
Dr. David Corry adatero.David Corry ndi Wapampando wa Pathology ku Fulbright Foundation komanso pulofesa wa matenda, chitetezo chamthupi, ndi mankhwala ku yunivesite ya Baylor.Iyenso ndi membala wa Baylor L. Duncan Comprehensive Cancer Center.Mu 2019, tidapeza kuti ma Candida albicans adalowadi muubongo ndikupanga kusintha kofanana ndi matenda a Alzheimer's.Kutupa komwe kumayambitsidwa ndi Candida albicans nthawi zambiri kumatsagana
A β Chifukwa chopangira ma amyloid ngati ma peptides ndikuti Sap imatha hydrolyze amyloid precursor proteins (APPs).
Komabe, ma peptides awa amakopa chidwi cha maselo oteteza muubongo - microglia, yomwe ndiyofunikira kuti ma Candida albicans achotsedwe ndi ubongo womwewo.Kuphatikiza apo, poizoni wa Candidalysin wopangidwa ndi Candida albicans amayendetsa microglia kudzera munjira ina.Ngati njira iyi yasokonezedwa, bowa mu ubongo sungachotsedwe.
Ofufuza akuwonetsa kuti ntchitoyi ingakhale yofunikira kwambiri pakumvetsetsa zomwe zimachitika kwa matenda a Alzheimer's.Kafukufuku wam'mbuyomu adawonetsa kuti ma protease muubongo amatenga nawo gawo pakuwonongeka kwa mapulogalamu ndipo amathandizira ku A β Kuwunjika kwa kwayala maziko.Ndipo tsopano zitha kutsimikiziridwa kuti protease yachilendo iyi yochokera ku bowa imathanso kuyambitsa A β Peptide ngati kupanga.
Ofufuza akuwonetsa kuti kuwunika kwina kwa ntchito ya Candida albicans pakukula kwa matenda a Alzheimer ndikofunikira m'tsogolomu, zomwe zingayambitsenso njira zatsopano zochizira AD.
Zolozera:
[1] Yifan Wu et al, Toll like receiver 4 ndi CD11b zosonyezedwa pa microglia coordinate erasure of Candida albicans cerebral mycosis, Cell Reports (2023) DOI: 10.1016/j.celrep.2023.113240
[2] Ubongo umagwira ntchito ndi matenda a Alzheimer's monga kusintha, atero kafukufuku watsopano Watulutsidwa pa Okutobala 17, 2023 kuchokera ku https://medicalxpress.com/news/2023-10-brain-fungal-infection-alzheimer-disease-like.html
Nthawi yotumiza: Dec-22-2023